Aplikasi Metode Spektrofotometri-UV Pada Penentuan Kadar Cetirizine Tablet Generik Dan Nama Dagang

Abstract

Cetirizine is a very strong and very specific antihistamine, cetirizine is also used as a strong and effective drug in treating allergic conjunctivitis such as eye inflammation, skin allergies, respiratory infections and other allergic reactions. Rhinitis is an inflammation of the nose when the immune system reacts to airborne allergens. The purpose of this study was to determine the differences in the levels of cetirizine in generic and trade name tablets. This research is descriptive by using ultraviolet spectrophotometric method. The samples used in this study were 4 tablets of cetirizine, 0.1 N hydrochloride as a solvent and a wavelength of 231 nm. From the test results on the samples, the cetirizine levels in the four samples were Ce (96.43%), Sahado (99.65%), Ryv (104.45%), and Oz (101.330%). The results showed that the level of cetirizine in the tablet preparation met the requirements of the Indonesian Pharmacopoeia Edition IV 2014 which was not less than 90% and not more than 110% of the amount stated on the label.