Kajian Sistematis Khasiat Empiris dan Farmakologis Formula Herbal Bu Zhong Yi Qi Tang
DOI:
https://doi.org/10.47861/usd.v1i2.389Keywords:
Bu Zhong Yi Qi Tang, Bojungikki-tang, Hochu-ekki-to, Traditional Chinese MedicineAbstract
Background: Bu Zhong Yi Qi Tang (BZYQT) is a classic traditional chinese medicine herbal formula with tonic property which is used widely by the people. Scientific researches have been done abundantly to explore the empirical claims of BZYQT in line with its pharmacologic effects. Methods: This article is a systematic review of published evidences about the empirical and pharmacological effects of BZYQT available from Sciencedirect, PubMed and CNKI data bases. Results: BZYQT has been empirically used as a central Qi tonic or energy enhancer. Pharmacologic studies indicate its effects encompass regulating various aspects of gastrointestinal function, antitumor effects, immune stimulant, and others. Conclusions: The empirical effects of BZYQT have been proven scientifically in regulation of various gastrointestinal functions, immune stimulation, antitumor, and others.
References
Akihiko Komuro, Chapter 14 - Kampo Medicines for Infectious Diseases, Editor(s): Somasundaram Arumugam, Kenichi Watanabe, Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation, Academic Press, 2017, Pages 127-142, ISBN 9780128093986, https://doi.org/10.1016/B978-0-12-809398-6.00014-7; (https://www.sciencedirect.com/science/article/pii/B9780128093986000147)
Chen Huaxian;Xiao Guozhong;Liu Fang;Lin Hongcheng (2023). Study on the mechanism of Buzhong Yiqi Decoction in the treatment of rectal prolapse: related analysis of single-cell transcriptome sequencing based on surgical excision specimens. Journal of Colorectal ＆ Anal Surgery. 2023(01) Page:38-46. 陈华显,肖国中,刘访,林宏城.补中益气汤治疗直肠脱垂的作用机制研究：基于手术切除标本的单细胞转录组测序相关分析[J].结直肠肛门外科,2023,29(01):38-46.DOI:10.19668/j.cnki.issn1674-0491.2023.01.008.
CHEN Qi; SONG Jixian; TANG Yi; SI Jianchao; YANG Xinyue; JI Ensheng; LI Jieru (2023). Buzhong Yiqitang reduces CIH-induced pulmonary inflammatory injury by ACE2-Ang(1-7)-Mas axis. Chinese Journal of Experimental Traditional Medical Formulae. 陈琦,宋纪显,唐毅,司建超,杨新栎,吉恩生,李杰茹.补中益气汤基于ACE2-Ang(1-7)-Mas轴减轻CIH诱发的肺脏炎症损伤[J/OL].中国实验方剂学杂志:1-8[2023-04-29].DOI:10.13422/j.cnki.syfjx.20230806.
DUAN Liuhua; LI Xiaohua (2023). Clinical Observation on Buzhong Yiqi Decoction in the Treatment of Chronic Gastritis with Deficiency of Spleen and Stomach Type. Chinese Medicine Modern Distance Education of China. 2023(05) Page:81-83.段柳花 & 李小花.(2023).补中益气汤治疗脾胃虚弱型慢性胃炎临床观察. 中国中医药现代远程教育(05),81-83. doi:CNKI:SUN:ZZYY.0.2023-05-029.
Guan Donglong; Hu Yamin; Qiu Xiangyu; Wu Shiguo. Current Status and Hotspots of Research on Bu Zhong Yi Qi Decoction——A Visual Analysis Based on CiteSpace. Liaoning Journal of Traditional Chinese Medicine. 关东龙,虎娅敏,邱祥玉,吴施国.补中益气汤的研究现状及热点——基于CiteSpace的可视化分析[J/OL].辽宁中医杂志:1-15[2023-04-29].http://kns.cnki.net/kcms/detail/21.1128.R.20230213.1111.069.html.
Huang XL (2023). Clinical efficacy of tonifying and invigorating qi decoction plus minus in the treatment of qi deficiency and blood stasis type postpartum lochia. Chinese Journal of Clinical Rational Drug Use. 2023(06) Page:127-130. 黄熙玲.(2023).补中益气汤加减治疗气虚血瘀型产后恶露不绝的临床疗效. 临床合理用药(06),127-130. doi:10.15887/j.cnki.13-1389/r.2023.06.038.
Jeong, M. K., Kim, Y. E., Kim, A., Jung, J., & Son, M. J. (2019). The herbal drug, Bu-Zhong-Yi-Qi-Tang, for the treatment of atopic dermatitis: Protocol for a systematic review. Medicine, 98(1), e13938. https://doi.org/10.1097/MD.0000000000013938:
JIA Lihua, KUANG Haodan & XU Yuan.(2023).Efficacy of Buzhong Yiqi decoction(补中益气汤)on benign prostatic hyperplasia and its possible mechanism. Journal of Traditional Chinese Medicine(03),533-541. doi:10.19852/j.cnki.jtcm.2023.03.003. https://www.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDAUTO&filename=ZYYW202303011&uniplatform=OVERSEA&v=lnBalhS98F0-_IQZNkO-Frmwm1mLpcck8NH1Gxs3l9Zgns4mkDJNMrR1noPPqJ-G.
Jiang Aiping; Zhong Qiaoling; Hang Yan (2022). Effect of Buzhong Yiqi Decoction on the hormones in patients with a cancer-related fatigue in the convalescent stage of lung cancer. 姜爱萍,仲巧玲 & 杭燕.(2022).补中益气汤治疗肺癌康复期癌因性疲乏. 吉林中医药(11),1294-1297. doi:10.13463/j.cnki.jlzyy.2022.11.013.
Ji YB季宇彬(ed.). Bab 8, Formula Tonik. Di dalam: Farmakologi formula herbal dan aplikasinya 复方中药药理与应用(chn). China Medical Science Publisher中国医药科技出版社, Beijing. 2005, pp.414-429. ISBN 7506732106/R2670.
Lee, J. A., Jang, S., Jun, J. H., Lee, M. S., Lee, E., Kim, N., & Lee, D. H. (2018). Herbal medicine (Bojungikki-tang) for allergic rhinitis: A protocol for a systematic review of controlled trials. Medicine, 97(3), e9551. https://doi.org/10.1097/MD.0000000000009551.
LIU Cheng; FU Jiaomei; FANG Yang; WU Baozhen; ZHANG Daoping; HE Zelong (2023). Mechanism of Buzhong Yiqi Decoction（补中益气汤） in Treating Chronic Fatigue Syndrome Based on Network Pharmacology and Molecular Docking. Journal of Practical Traditional Chinese Internal Medicine. 刘成,扶姣梅,方杨,吴宝珍,张道平 & 贺泽龙..基于网络药理学和分子对接探讨补中益气汤治疗慢性疲劳综合征的机制. 实用中医内科杂志. Mechanism of Buzhong Yiqi Decoction(补中益气汤) in Treating Chronic Fatigue Syndrome Based on Network Pharmacology and Molecular Docking - CNKI
Niu YO (2023). Clinical Observation on Modified BuzhongYiqi Decoction in Treating Primary Hypothyroidism. Chinese Medicine Modern Distance Education of China. 2023(05) Page:86-88. 牛亚欧.(2023).加味补中益气汤治疗原发性甲状腺功能减退症临床观察. 中国中医药现代远程教育(05),86-88. doi:CNKI:SUN:ZZYY.0.2023-05-031.
Vengadeshprabhu Karuppagounder, Mayumi Nomoto, Kenichi Watanabe, Chapter 10 - Antiinflammatory Effects of Kampo Medicines in Atopic Dermatitis, Editor(s): Somasundaram Arumugam, Kenichi Watanabe, Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation, Academic Press, 2017, Pages 89-95, ISBN 9780128093986, https://doi.org/10.1016/B978-0-12-809398-6.00010-X. (https://www.sciencedirect.com/science/article/pii/B978012809398600010X)
Wiki8.com (2020). Bu Zhong Yi Qi Tang. Available from: 补中益气汤_补中益气汤的组成、功效、方解、适应证、药理作用、用法用量_医学百科 (wiki8.com)
Wikipedia (2022). Bu Zhong Yi Qi Tang. Available from: Bu Zhong Yi Qi Tang - Wikipedia.
Xingyi (2011). Bu Zhong Yi Qi Tang. Available from: http://www.a-hospital.com/w/%E8%A1%A5%E4%B8%AD%E7%9B%8A%E6%B0%94%E6%B1%A4.
Yakabe, M., Hosoi, T., Sasakawa, H., Akishita, M., & Ogawa, S. (2022). Kampo formula hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang, TJ-41) ameliorates muscle atrophy by modulating atrogenes and AMPK in vivo and in vitro. BMC complementary medicine and therapies, 22(1), 341. https://doi.org/10.1186/s12906-022-03812-w.
YU Jianhua,JIANG Zhenglong,WANG Ningjun,FENG Li,WANG Wenling. Jilin Journal of Traditional Chinese Medicine,2019,39(07):886-889.DOI:10.13463/j.cnki.jlzyy.2019.07.013.
ZHU Minghui; CAO Jing; ZHOU Xi;LI Yanfei (2023). Effect of Buzhong Yiqi Decoction on bone marrow suppression and quality of life in elderly patients with advanced digestive system malignant tumors. China Medical Herald. 2023(05) Page:90-93+97. 朱明辉,曹静,周玺 & 李雁飞.(2023).补中益气汤对老年晚期消化系统恶性肿瘤骨髓抑制及生活质量的影响. 中国医药导报(05),90-93+97. doi:10.20047/j.issn1673-7210.2023.05.21.
